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KMID : 1161420220250060675
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Journal of Medicinal Food
2022 Volume.25 No. 6 p.675 ~ p.682
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Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 2 Diabetic Subjects
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Buch Assaf
Ganz Tali
Wainstein Julio
Gilad Suzan
Limor Rona
Shefer Gabi
Boaz Mona
Stern Naftali
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Abstract
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Since low serum l-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested whether Arg and ADMA are affected by diet and physical activity in overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA of single loads of dextrose, protein, fat, or alcohol (∼300 calories each); one episode of physical exercise; and 12 weeks of standard lifestyle modification (dietary and physical activity counseling). Alcohol drink was followed by ∼30% lowering in Arg. Arg and ADMA increased after a protein load but remained stable after glucose or fat load or 30?min of treadmill walk. Following 12 weeks of lifestyle modification, ADMA declined only in subjects achieving weight loss >5%. In conclusion, alcohol is a previously unrecognized acute suppressor of serum Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss >5%.
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KEYWORD
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arginine, asymmetric dimethylarginine, diabetes mellitus, metabolic syndrome, obesity
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